AMT Medical Laboratory Scientist (MLS) 2025 – 400 Free Practice Questions to Pass the Exam

Autocontrol in crossmatching tests refers specifically to the practice of using recipient serum combined with the recipient's own red blood cells (RBCs). This procedure is performed to determine if the recipient's serum contains any antibodies that would react against their own RBCs, thereby indicating a potential for hemolytic transfusion reactions. By conducting this test, clinicians can assess whether the patient has developed antibodies against their own blood cells, which could complicate transfusions.

This method serves as an important self-check in the blood transfusion process, ensuring that the intended blood product is indeed compatible with the patient’s own red blood cells. The presence of unexpected antibodies in the recipient's serum would be flagged, influencing the decision-making process regarding transfusions.

Other options provided do not accurately define autocontrol. The comparison of donor serum with recipient RBCs relates more to compatibility testing rather than autocontrol. Validation of reagent effectiveness and quality control measures for equipment refer to different aspects of laboratory practices that do not specifically focus on the individual patient's blood compatibility assessment via their own serum and RBCs.